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class='possplit'>  </span><a href="/6613/list.htm" target="_self">鏁 鎺圏/a></div> </div> <div frag="绐楀彛062" portletmode="simpleArticleAttri"> <div class="page-con-title page-con-title1"> <h2>璋皬鏈圏/h2> </div> <div class="page-news-con" style="padding-top:20px;"> <div class='wp_articlecontent'><p style="text-align: center"><img height="289" width="250" src="/_upload/article/images/0c/2e/e16e6ccd4d559a25443983c960ac/5801b343-2f2e-4fd8-a937-037e12c3ad73.jpg" alt="" /></p><p style="text-align: left"> </p><p style="text-align: left;">濮撳悕锛氳碍灏忔湀<br />鑱岀О锛氭暀鎺圏br />涓€銆佹暀鑲茬粡鍘咟br />2001.9-2004.7涓浗鍖诲绉戝闄?涓浗鍗忓拰鍖荤澶у鍖椾含鍗忓拰鍖婚櫌, 鍖诲鍗氬+瀛︿綅<br />1991.9-1998.7婀栧崡鍖荤澶у涓村簥鍖诲绯讳竷骞村埗, 鍖诲纭曞+瀛︿綅<br />浜屻€佸伐浣滅粡鍘咟br />2013.12- 鍗楀紑澶у鍖诲闄紝鏁欐巿<br />2008.06-2013.12 鍗楀紑澶у鍖诲闄紝鍓暀鎺圏br />2004.08-2008.05 缇庡浗鍖瑰吂鍫″ぇ瀛﹀尰瀛︿腑蹇冪梾鐞嗙郴 鍗氬+鍚嶞br />1998.08-2001.08 涓崡澶у婀橀泤鍖诲闄㈤檮灞炵浜屽尰闄 鍖诲笀<br />涓夈€佺爺绌舵柟鍚慄br />1锛 绾ょ淮鍖栫浉鍏宠偪鐦ゅ井鐜缁存寔鑲跨槫骞茬粏鑳?ldquo;niche”鐨勬満鍒迭br />2. 涓婄毊鍚戦棿鍏呰川杞垎鍖栧湪鑲跨槫杞Щ鍙婄氦缁村寲褰㈡垚涓殑浣滅敤锛汓br />3锛 Vitamin D鍙婂叾鍙椾綋鍦ㄦ不鐤楃氦缁村寲鐩稿叧鐤剧梾涓殑浣滅敤鍙婂叾鏈哄埗銆侟br />浣滀负椤圭洰璐熻矗浜虹殑绉戠爺椤圭洰锛欬br />鈶犲ぉ娲ュ競鑷劧绉戝鍩洪噾闈笂椤圭洰锛?016-2018锛堻br />M2宸ㄥ櫖缁嗚優閫氳繃legumain閲嶅鑲跨槫寰幆澧冪殑鏈哄埗鐮旂┒<br />鈶″浗瀹惰嚜鐒剁瀛﹀熀閲戦潰涓婇」鐩 锛?012-2016): <br />M2宸ㄥ櫖缁嗚優琛ㄨ揪Legumain淇冭繘鑲鹃棿璐ㄧ氦缁村寲鎹熶激淇鐨勬満鐞嗗強搴旂敤鐮旂┒ <br />鈶 2013骞村害鏁欒偛閮?ldquo;鏂颁笘绾紭绉€浜烘墠鏀寔璁″垝”( 2014-2016):<br />绾ょ淮鍖栧叧閿皟鎺ц泲鐧藉弬涓庤偪鐦ゅ共缁嗚優niche褰㈡垚<br />鈶 鍥藉鑷劧绉戝鍩洪噾闈掑勾鍩洪噾 (30900540, 2010-2013): <br />缁寸敓绱犲彈浣撲粙瀵肩値鐥囦績杩涜偩灏忕涓婄毊缁嗚優鍚戦棿鍏呰川杞垎鍖栫殑浣滅敤鐮旂┒ <br />鈶 澶╂触甯傚簲鐢ㄥ熀纭€涓庡墠娌挎妧鏈爺绌惰鍒掗噸鐐归」鐩? 2009-2012) <br />缁寸敓绱燚娌荤枟鎱㈡€ц偩闂磋川绾ょ淮鍖栫殑鏈虹悊鐮旂┒ <br />鈶ユ暀鑲查儴鍥炲浗鐣欏浜哄憳鍚姩鍩洪噾 (2010-2012) <br />缁寸敓绱燚鍙椾綋婵€鍔ㄥ墏鍦ㄦ參鎬ц偩鐥呬腑鐨勬不鐤椾綔鐢?br />浣滀负璇鹃楠ㄥ共鍙備笌绉戠爺椤圭洰<br />鈶 鍥藉閲嶅ぇ鐮旂┒璁″垝椤圭洰(2011-2015 )<br />鍝轰钩鍔ㄧ墿鍚庤偩鍙戣偛閲嶈鐜妭鍙婂叧閿皟鎺у洜瀛愮殑鐮旂┒<br />鈶 鍥藉閲嶅ぇ鐮旂┒璁″垝椤圭洰(2012-2016 )<br />鑲跨槫骞茬粏鑳炲湪瀹炰綋鑲跨槫鍙戝睍涓殑璋冩帶鏈哄埗鐮旂┒<br />鍥涖€佸鏈吋鑱孅br />1锛 Member of AACR (缇庡浗鑲跨槫鐮旂┒鍗忎細浼氬憳) <br />2锛 Member of ASN (缇庡浗鑲捐剰鐥呭崗浼氫細鍛?<br />3锛 涓浗鎶楃檶鍗忎細浼氬憳<br />4. 鑷劧绉戝鍩洪噾闈掑勾鍩洪噾鍙娿€侀潰涓婇」鐩悓琛岃瘎璁笓瀹迭br />浜斻€佷富瑕佽鏂嘃br />1. Zhang Y, Shen L, Stupack DG, Bai N, Xun J, Ren G, Han J, Li L, Luo Y, Xiang R, Tan X#.JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms.Oncotarget. 2016 May 17;7(20):29387-99. <br />2.Shen L, Li H, Shi Y, Wang D, Gong J, Xun J, Zhou S, Xiang R, Tan X#.M2 tumour-associated macrophages contribute to tumour progression via legumainremodelling the extracellular matrix in diffuse large B cell lymphoma.Sci Rep. 2016 Jul 28;6:30347. <br />3. Shen L, Qin K, Wang D, Zhang Y, Bai N, Yang S, Luo Y, Xiang R, Tan X#. Overexpression of Oct4 suppresses the metastatic potential of breast cancer cells via Rnd1 downregulation. BiochimBiophysActa. 2014 Jul 25. <br />4. Liu Z, Xiong M, Gong J, Zhang Y, Bai N, Luo Y, Li L, Wei Y, Liu Y, Tan X#, Xiang R#. Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment. Nat Commun. 2014 Jun 27;5:4280. <br />5. Zhang Y, Guo Q, Zhang Z, Bai N, Liu Z, Xiong M, Wei Y, Xiang R#, Tan X#. VDR Status Arbitrates the Prometastatic Effects of Tumor-Associated Macrophages. Mol Cancer Res. 2014 Aug;12(8):1181-91.<br />6. Bai N, Zhang C, Liang N, Zhang Z, Chang A, Yin J, Li Z, Luo N, Tan X, Luo N, Luo Y, Xiang R, Li X, Reisfeld RA, Stupack D, Lv D, Liu C. Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53. Cancer BiolTher. 2013 Jun;14(6):511-20. <br />7. Liu Z, Lv D, Liu S, Gong J, Wang D, Xiong M, Chen X, Xiang R, Tan X#. Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: effect against breast cancer in mice. PLoS One. 2013;8(4):e60190. doi: 10.1371/journal.pone.0060190. <br />8. Xiong M, Gong J, Liu Y, Xiang R, Tan X#. Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchymal transition. Am J Physiol Renal Physiol. 2012 Oct;303(7):F1107-15. <br />9. Lu D, Chen S, Tan X, Li N, Liu C, Li Z, Liu Z, Stupack DG, Reisfeld RA, Xiang R. Fra-1 promotes breast cancer chemosensitivity by driving cancer stem cells from dormancy. Cancer Res. 2012 Jul 15;72(14):3451-6. <br />10. Zhang M, Liu M, Xiong M, Gong J, Tan X#. Schisandrachinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy. J Ethnopharmacol. 2012 May 7;141(1):111-8.<br />11. Zhang Z, Yin J, Zhang C, Liang N, Bai N, Chang A, Liu Y, Li Z, Tan X, Li N, Lv D, Xiang R, Tian Y, Liu C.Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma. Cancer BiolTher. 2012 Apr;13(6):435-42. <br />12. Hu J, Qin K, Zhang Y, Gong J, Li N, Lv D, Xiang R, Tan X#. Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. BiochemBiophys Res Commun. 2011 Aug 12;411(4):786-91. <br />13. Jia X, Li X, Xu Y, Zhang S, Mou W, Liu Y, Liu Y, Lv D, Liu CH, Tan X, Xiang R, Li N. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. J Mol Cell Biol. 2011 Aug;3(4):230-8. <br />14. Tan X, He W, Liu Y. Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy. Kidney Int. 2009;76:1248-1257. (IF= 6.193)<br />15. Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am SocNephrol. 2009;20:1907-1918. (IF= 7.689)<br />16. Tan X, Wen X, Liu Y. Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling. J Am SocNephrol. 2008;19:1741-1752. (IF= 7.689)<br />17. Giannopoulou M*, Dai C*, Tan X*, Wen X, Michalopoulos GK, Liu Y. Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol. 2008;173:30-41. (*:co-first author) (IF= 5.673)<br />18. Hu K, Lin L, Tan X, Yang J, Bu G, Mars WM, Liu Y. .tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis. J Am SocNephrol. 2008;19:503-514. (IF= 7.689)<br />19. Tan X, Li Y and Liu Y. Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosis.J Steroid BiochemMol Biol. 2007: 103: 491-496. (IF= 2.655)<br />20. Tan X, Li Y, Liu Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy.J Am SocNephrol. 2006;17:3382-3393(IF= 7.689)<br />21. Tan X, Zheng FL, Yang JH, Duan L, Li Y, Zhou QG. Effect of BMP-7 on the transdifferentiation of cultured human tubular epithelial cell induced by TGF-beta1. ACTA ACADEMIAE MEDICINAE SINICAE, 2004;26:274-278.<br />22. Tan X, Zheng FL, Zhou QG, Duan L, Li Y. Effect of bone morphogenetic protein-7 on monocyte chemoattractant protein-1 induced epithelial-myofibroblast transition and TGF-beta1-Smad 3 signaling pathway of HKC cells. National Journal of China. 2005;85: 2607-2612.<br />23. Giannopoulou M, Iszkula SC, Dai C, Tan X, Yang J, Michalopoulos GK, Liu Y. Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action. Am J Physiol Renal Physiol. 2006;290:F1234-1240. (IF=3.731)<br />24. Tan R, Zhang J, Tan X, Zhang X, Yang J, Liu Y. Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation. J Am SocNephrol. 2006;17:2781-2791. (IF= 7.689)<br />25. Zhou QG, Zheng FL, Wen YB, Tan X, Duan L, Li Y. Altered expression of vascular endothelial growth factor and its receptors in transdifferentiated human proximal tubular epithelial cells induced by transforming growth factor beta1. ACTA ACADEMIAE MEDICINAE SINICAE.2005;27: 325-331.<br />鍏€佽鎺堣绋婞br />1锛 鐥呯悊瀛︼紙涓村簥鍖诲绯讳竷骞村埗&涓村簥鍖诲绯诲叓骞村埗&鍙h厰鍖诲绯讳簲骞村埗锛堻br />2. 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