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鍒樺

涓€銆佹暀鑲茬粡鍘嗭細

2003/9 - 2008/7锛屼腑鍥藉尰瀛︾瀛﹂櫌鍖椾含鍗忓拰鍖荤澶у锛岀粏鑳炵敓鐗╁锛屽崥澹

1996/9 - 2001/7锛屼腑鍥借嵂绉戝ぇ瀛︼紝鑽悊瀛︼紝瀛﹀+

 

浜屻€?/span>绉戠爺涓庡鏈伐浣滅粡鍘嗭細

2021/1 - 鐜板湪锛孅span lang="EN-US">   鍗楀紑澶у锛屽尰瀛﹂櫌锛岀爺绌跺憳

2016/7 - 2020/12锛屽崡寮€澶у锛屽尰瀛﹂櫌锛屽壇鐮旂┒鍛楛/span>

2012/12016/07锛屽崡寮€澶у锛岀敓鍛界瀛﹀闄紝鍓爺绌跺憳

2013/8 - 2014/08锛岃€堕瞾澶у锛岄仐浼犵郴锛岃闂鑰匋/span>

2008/7 - 2011/12锛屽崡寮€澶у锛岀敓鍛界瀛﹀闄紝璁插笀

 

涓夈€佺爺绌舵柟鍚戯細骞茬粏鑳炵敓鐗╁

锛堜竴锛堻/span>鐮旂┒棰嗗煙

1銆?/span>鑳氳儙骞茬粏鑳炲叏鑳芥€х淮鎸佸垎瀛愭満鍒迭/span>

2銆?/span>骞茬粏鑳炴姷寰℃満浣撹“鑰佺瓥鐣ュ強鏈哄埗

3銆?/span>骞茬粏鑳炲垎鍖栬皟鎺у強浣撳唴绀鸿釜

锛堜簩锛夌鐮旈」鐩?/span>

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2.  鍥藉鑷劧绉戝鍩洪噾锛欬span lang="EN-US">31771636锛孅span lang="EN-US">Lin28a璋冩帶ES缁嗚優na茂ve-primed鐘舵€佽浆鍙樻満鍒剁爺绌讹紝2018.1-2021.12 涓绘寔

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8.  涓浗浜烘皯瑙f斁鍐涙€诲尰闄㈣偩鑴忕柧鐥呭浗瀹堕噸鐐瑰疄楠屽寮€鏀捐棰橈細KF-19-07, MSC鑱斿悎ES-EV鍦ㄦ€ユ€ц偩鎹熶激娌荤枟涓殑浣滅敤, 2020.1-2021.12,涓绘寔

9.  鍥藉閲嶅ぇ绉戝鐮旂┒璁″垝锛氱绮掔浉鍏宠泲鐧藉湪鍩哄洜琛ㄨ揪璋冩帶鍙婄粏鑳炲垎鍖栦腑鐨勪綔鐢紝 2012.1-2016.8锛屽崡寮€澶у鍞竴鍙備笌浜裹/span>

10.鍥藉閲嶇偣鐮斿彂璁″垝锛欬span lang="EN-US">2017YFA0103201, 涓嶅悓鑳氬眰鏉ユ簮鍣ㄥ畼鎹熶激鍚庡啀鐢熺粏鑳炲懡杩愬強璋冩帶鐢熺悊鎬т慨澶嶇殑鐮旂┒锛孅span lang="EN-US">2017.1-2021.8锛屽弬涓嶞/span>

11.鍥藉閲嶅ぇ绉戝鐮旂┒璁″垝锛欬span lang="EN-US">2009CB941000锛岀尓璇卞澶氳兘骞茬粏鑳烇紙iPS锛夊強鍏跺垎鍖栧彂鑲茬爺绌讹紝 2009.1-2013.8锛屽弬涓嶞/span>

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13.鍥介檯鍚堜綔椤圭洰锛氬崟缁嗚優鎶€鏈爺绌惰偪鐦ゅ共缁嗚優鏍囧織鍜屾柊鑽爺鍙戯紝 2013.1-2016.12锛屽弬涓嶞/span>

14.鍥藉杞熀鍥犻噸澶т笓椤更/span>锛欬span lang="EN-US">2009ZX08006-010B锛屽埄鐢ㄧ敓娈栫郴澶氳兘鎬у共缁嗚優鏋勫缓楂樻晥鐨勫煿鑲蹭紭鑹搧绉嶇尓鍜岃浆鍩哄洜鐚殑鏂版妧鏈钩鍙帮紝2009.1-2010.12锛岀爺绌堕骞秉/span>

15.鍥藉鑷劧绉戝鍩洪噾閲嶇偣椤圭洰锛欬span lang="EN-US">31430052绔矑鍐嶇敓涓庡嵉宸㈠姛鑳介噸寤裹/span>锛孅span lang="EN-US">2015.1-2018.12锛岀爺绌堕骞秉/span>

 

鍥涖€佸鏈吋鑱孅/span>

1銆佷腑鍥界敓鐗╁尰瀛﹀伐绋嬪浼氬共缁嗚優宸ョ▼鎶€鏈垎浼氬鍛楛/span>

2銆?/span>鍥藉鑷劧绉戝鍩洪噾閫氳璇勫涓撳

3銆佹暀鑲查儴瀛︿綅涓績瀛︿綅璁烘枃璇勫涓撳

4銆佹渤鍖楃渷绉戞妧璁″垝椤圭洰缃戠粶璇勫涓撳

 

浜斻€佸彂琛ㄦ枃绔狅細

[1]     Hui Sang, Dan Wang, Shuang Zhao, Jinxin Zhang, Yan Zhang, Jia Xu, Xiaoniao Chen, Yan Nie, Kaiyue Zhang, Shuaiqiang Zhang, Yuebing Wang, Na Wang, Fengxia Ma, Ling Shuai, Zongjin Li, NaLiu*. Dppa3 is critical for Lin28a-regulated ES cells na茂ve鈥抪rimed state conversion. J Mol Cell Biol. 2019 Jun 1; 11(6):474-488. Corresponding Author

[2]     Yan Zhang, Jia Xu, Siying Liu, Meikuang Lim, Shuang Zhao, Kaige Cui, Kaiyue Zhang, Lingling Wang, Qian Ji, Zhongchao Han, Deling Kong, Zongjin Li, Na Liu*. Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells. Theranostics, 2019; 9(23):6976-6990. Corresponding Author

[3]     Na Liu#, Yu Yin#, Haiying Wang#, Zhongcheng Zhou, Xiaoyan Sheng, Haifeng Fu, Renpeng Guo, Hua Wang, Jiao Yang, Peng Gong, Wen Ning, Zhenyu Ju, Yifei Liu*, Lin Liu*. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling. PLoS Genet. 2019; 15(9): e1008368. First Author

[4]     Dan J#, Liu Y#, Liu N#, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A*, Liu L*. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014 Apr 14;29(1):7-19. First Author

[5]     Lu Yu, Siying Liu, Chen Wang, Chuanyu Zhang, Yajie Wen, Kaiyue Zhang, Shang Chen, Haoyan Huang, Yue Liu, Lingling Wu, Zhongchao Han, Xiangmei Chen*, Zongjin Li*, Na Liu*. Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury. Stem Cell Res Ther. 2021 Jul 2; 12(1):379. Corresponding Author

[6]     Wang D, Sang H, Zhang K, Nie Y, Zhao S, Zhang Y, He N, Wang Y, Xu Y, Xie X, Li Z, Liu N*. Stat3 phosphorylation is required for embryonic stem cells ground state maintenance in 2i culture media. Oncotarget. 2017 May 9;8(19):31227-31237. Corresponding Author

[7]     Yu Yin#, Na Liu#, Xiaoying Ye, Renpeng Guo, Jie Hao, Fang Wang, Lin Liu. Telomere elongation in parthenogenetic stem cells. Protein 锛咟/span>Cell. 2014 5(1):8-11 First Author

[8]     Yin Y, Wang H, Liu K, Wang F, Ye X, Liu M, Xiang R, Liu N*, Liu L*. , Knockdown of H19 enhances differentiation capacity to epidermis of parthenogenetic embryonic stem cells. Current Molecular Medicine, 2014;14(6):737-48. Corresponding Author

[9]     Zhenrong Zhao, Xinghua Pan, Lin Liu and Na Liu*. Telomere Length Maintenance, Shortening, and Lengthening. J Cell Physiol. 2014; 229(10):1323-9. Corresponding Author

[10]  Na Liu*, Lin Liu & Xinghua Pan. Single鈥慶ell analysis of the transcriptome and its application in the characterization of stem cells and early embryos. Cell. Mol. Life Sci. (2014) 71:2707鈥?715 First Author and Corresponding Author

[11]  Shuang Zhao, Jia Xu, Siying Liu, Kaige Cui, Zongjin Li, NaLiu*.Dppa3 in pluripotency maintenance of ES cells and early embryogenesis. Journal of Cellular Biochemistry, 2019 Apr;120(4):4794-4799. Corresponding Author

[12]  Yan ZhangDan WangJia XuYuebing WangFengxia MaZongjin Li, Na Liu*. Stat3 activation is critical for pluripotency maintenance. J Cell Physiol. 2019 Feb;234(2):1044-1051. Corresponding Author

[13]  Liu N, Enkemann SA, Liang P, Hersmus R, Zanazzi C, Huang J, Wu C, Chen Z, Looijenga LH, Keefe DL, Liu L. Genome-wide Gene Expression Profiling Reveals Aberrant MAPK and Wnt Signaling Pathways Associated with Early Parthenogenesis. J Mol Cell Biol. 2010, 2(6):333-344. First Author

[14]  Nie Y, Zhang K, Zhang S, Wang D, Han Z, Che Y, Kong D, Zhao Q, Han Z, He ZX, Liu N*, Ma F*, Li Z*.Nitric oxide releasing hydrogel promotes endothelial differentiation of mouse embryonic stem cells.Acta Biomater. 2017 Nov;63:190-199.  Corresponding Author

[15]  Ningning HeGuowei FengYang LiYang XuXiaoyan XieHui WangYuebing WangLailiang Ou, Xuetao PeiNa Liu*, and Zongjin Li*. Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer. Stem Cell Res Ther. 2016, 7(1):95 Corresponding Author

[16]  Liu N, Lu M, Feng XM, Ma FX, Fang ZH, Tian XM, Ren Q, Zhang L, Liu B, Huang PP, Liu L, Han ZC. Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition.J Cell Biochem. 2009, 106(6):1041-1047.First Author

[17]  Liu N, Feng X, Fang Z, Ma F, Lu S, Lu M, Han Z. Identification of Genes Regulated by Nanog Which Is Involved In ES Cells Pluripotency and Early Differentiation. J Cell Biochem.2008, 104(6):2348-2362.First Author

[18]  Liu N, Lu M, Tian X, Han Z.Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J Cell Physiol. 2007, 211(2):279-286.First Author

[19]  Liu N, Lu M. The signal transduction pathways and molecules for ES cells self-renewal, Chinese Science Bulletin. 2005, 50(8):721-726.First Author

[20]  Na Liu,  Xin Qi, Zhibo Han, Lu Liang, Deling Kong, Zhongchao Han, Shihua Zhao, Zuo-Xiang He, and Zongjin Li*. Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells. Sci Rep. 2016, 6:28739. First Author

[21]  Chen Wang, Guoyun Li, Kaige Cui, Zihan Chai, Ziyu Huang, Yue Liu, Shang Chen, Haoyan Huang, Kaiyue Zhang, Zhibo Han, Yuhao Li, Guangli Yu, Zhong-Chao Han, Na Liu*, Zongjin Li*. Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing. Acta Biomater. 2021 Mar 1;122:199-210. Corresponding Author

[22]  Liang L, Yue Z, Du W, Li Y, Tao H, Wang D, Wang R, Huang Z, He N, Xie X, Han Z, Liu N*, Li Z*. Molecular Imaging of Inducible VEGF Expression and Tumor Progression in a Breast Cancer Model. Cell Physiol Biochem. 2017 May 25;42(1):407-415. Corresponding Author

[23]  Huifang Li, Haoyan Huang, Xiaoniao Chen, Shang Chen, Lu Yu, Chen Wang, Yue Liu, Kaiyue Zhang, Lingling Wu, Zhong-Chao Han, Na Liu*, Jie Wu*, Zongjin Li*. The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis. Stem Cell Res Ther. 2021 Jan 22;12(1):77. Corresponding Author

[24]  Anan Huang, Danni Liu, Xin Qi, Zhiwei Yue, Hongmei Cao, Kaiyue Zhang, Xudan Lei, Youzhi Wang, Deling Kong, Jie Gao, Zongjin Li, NaLiu*, Yuebing Wang*. Self-Assembled GFFYK Peptide Hydrogel Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells in a Mouse Hindlimb Ischemia Model. Acta Biomater. 2019 Feb;85:94-105. doi: 10.1016/j.actbio.2018.12.015. Corresponding Author

[25]  Cao X, Duan L, Hou H, Liu Y, Chen S, Zhang S, Liu Y, Wang C, Qi X, Liu N, Han Z, Zhang D, Han ZC, Guo Z, Zhao Q, Li Z. IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE2-mediated M2 macrophage polarization. Theranostics. 2020. DOI: 10.7150/thno.45434 PMID: 32685014

[26]  Kaiyue Zhang, Xiangnan Zhao, Xiaoniao Chen, Yongzhen Wei, Wei Du, Yuebing Wang, Linan Liu, Weian Zhao, Zhibo Han, Deling Kong, Qiang Zhao, Zhikun Guo, Zhongchao Han, Na Liu, Fengxia Ma *, Zongjin Li*. Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment. ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30081-30091..

[27]  He N, Chen X, Wang D, Xu K, Wu L, Liu Y, Tao H, Zhao Q, Cao X, Li Y, Liu N, Qi X, Han Z, Kong D, Yang J, Li Z. VE-Cadherin regulates the self-renewal of mouse embryonic stem cells via LIF/Stat3 signaling pathway. Biomaterials. 2017 Dec 16;158:34-43.

[28]  Liu Y, Song B, Wei Y, Chen F, Chi Y, Fan H, Liu N, Li Z, Han Z, Ma F.Exosomes from mesenchymal stromal cells enhance imatinib-induced apoptosis in human leukemia cells via activation of caspase signaling pathway. Cytotherapy. 2017 Dec 18. pii: S1465-3249(17)30733-8.

[29]  Wang R, Zhang K, Tao H, Du W, Wang D, Huang Z, Zhou M, Xu Y, Wang Y, Liu N, Wang H, Li Z. Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence. Curr Pharm Biotechnol.  2017;18(5):422-428.

[30]  Du W, Zhang K, Zhang S, Wang R, Nie Y, Tao H, Han Z, Liang L, Wang D, Liu J, Liu N, Han Z, Kong D, Zhao Q, Li Z. Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer. Biomaterials. 2017 Jul;133:70-81.

[31]  Liu K, Mao J, Song L, Fan A, Zhang S, Wang J, Fan N, Liu N, Ye X, Fu H, Zhou Z, Wang Y, Wei H, Liu Z, Li Z, Lai L, Wang X, Liu L. DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells. PLoS One. 2017 Mar 2;12(3):e0173047.

[32]  Song X, Liu D, Cui J, Zhou M, Wang H, Liu N, Qi X, Li Z. Identification of Stem-Like Cells in Atrial Myxoma by Markers CD44, CD19, and CD45. Stem Cells Int. 2016;2016:2059584.

[33]  Guowei Feng, Jimin Zhang, Yang Li, Yan Nie, Dashuai Zhu, Ran Wang, Jianfeng Liu, Jie Gao, Na Liu, Ningning He, Wei Du, Hongyan Tao, Yongzhe Che, Yong Xu, Deling Kong, Qiang Zhao, and Zongjin Li*. IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI. J Am Soc Nephrol. 2016, 27(8):2357-69. 

[34]  Wang D, Meng Q, Huo L, Yang M, Wang L, Chen X, Wang J, Li Z, Ye X, Liu N, Li Q, Dai Z, Ouyang H, Li N, Zhou J, Chen L, Liu L. Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice. Protein Cell. 2015, 6(2):152-6.

[35]  Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L. Piglets cloned from induced pluripotent stem cells. Cell Res. 2013, 23(1):162-6.

[36]  Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells. 2013 31(11):2538-50.

[37]  Ji G, Liu K, Okuka M, Liu N, Liu L. Association of telomere instability with senescence of porcine cells. BMC Cell Biol. 2012 Dec 15; 13:36.

[38]  Zuo B, Yang J, Wang F, Wang L, Yin Y, Dan J, Liu N, Liu L. Influences of lamin A levels on induction of pluripotent stem cells. Biol Open. 2012, 1(11):1118-27.

[39]  Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N, Steinhoff G, Liu L, Kong D. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovasc Res. 2012, 97(2):208-18.

[40]  Liu J, Liu M, Ye X, Liu K, Huang J, Wang L, Ji G, Liu N, Tang X, Baltz JM, Keefe DL, Liu L.Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC). Hum Reproduction. 2012; 27(5): 1411-1420.

[41]  Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.Cell Research. 2012; 22(4): 757-768.

[42]  Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L*. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Research. 2011, 21(5):779-92.

[43]  Fang ZH, Dong CL, Chen Z, Zhou B, Liu N, Lan HF, Liang L, Liao WB, Zhang L, Han ZC. Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy.J Cell Mol Med. 2009 13(8B):2039-52.

[44]  Feng XM, Liu N, Yang SG, Hu LY, Chen XL, Fang ZH, Ren Q, Lu SH, Liu B, Han ZC.Regulation of the class鈪狘/span> and class鈪燑/span>MHC pathways in human THP-1 monocytic cells by interleukin-27. Biochem Biophys Res Commun. 2008 14;367(3):553-9.

[45]  Feng XM, Chen XL, Liu N, Chen Z, Zhou YL, Han ZB, Zhang L, Han ZC. Interleukin-27 upregulates major histocompatibility complex class 鈪狘/span> expression in primary human endoghelial cells through induction of major histocompatibility complex class 鈪狘/span> trasactivator. Hum Immunol. 2007 68(12):965-72.

 

Books and Chapters:

[46]  Yin Y, Liu N, Keefe D, and Liu L.Parthenogenetic activation-induced pluripotent stem cells and potential applications. Stem Cells and Cancer Stem Cells. Volume 8. Hayat, MA (edt.) Springer, 2012, 235-246.

[47]  Yan Nie, Shuaiqiang Zhang, Na Liu,  Zongjin Li, Extracellular Matrix Enhances Therapeutic Effects of Stem Cells in Regenerative Medicine.  Composition and Function of the Extracellular Matrix in the Human Body. INTECH, 2016

[48]  Yan Zhang, Zongjin Li, and Na Liu*锛孅/span>The Stemness of Perinatal Stem Cell锛孅/span>Perinatal Stem CellsISBN 978-981-13-2702-5, ISBN 978-981-13-2703-2 (eBook)Springer Nature Singapore Pte Ltd. 2019

 

鍏€佽鎺堣绋婞/span>
1锛庣粏鑳炵敓鐗╁ (鏈鐢燂紝涓昏)
2
锛庡共缁嗚優涓庡啀鐢熷尰瀛 锛堢澹爺绌剁敓锛屼富璁诧級

3. 骞茬粏鑳炰笌鍐嶇敓鍖诲鍓嶆部 锛堝崥澹爺绌剁敓锛堻/span>

 

涓冦€佽崳瑾夊拰濂栧姳
1锛嶞span lang="EN-US">2012骞村崡寮€澶у鏁欏鎴愭灉濂 浜岀瓑濂朁/span>

2锛嶞span lang="EN-US">2016骞村崡寮€澶у闈掑勾鏁欏笀鏁欏鍩烘湰鍔熺珵璧 浜岀瓑濂朁/span>

3锛嶞span lang="EN-US">2016骞村ぉ娲ュ競闈掑勾鏁欏笀鏁欏鍩烘湰鍔熺珵璧 涓夌瓑濂朁/span>


鍏€佽仈绯绘柟寮廃/span>
1锛 閫氳鍦板潃锛氬ぉ娲ュ競鍗触璺?span lang="EN-US">94鍙峰崡寮€澶у鍖诲闄↑span lang="EN-US">304
2锛嶞span lang="EN-US"> E-mail锛欬span lang="EN-US">liuna@nankai.edu.cn